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Do marginal zone B cells express CD5?

Do marginal zone B cells express CD5?

Marginal-zone B cells MZ B cells express high levels of IgM, CD21, CD1, and CD9 and are low to negative for IgD, CD23, CD5, and CD11b, which distinguishes them from FO and B1 B cells (Fig. 4.4).

What is marginal zone of lymph node?

The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)

Do lymph nodes have marginal zone B cells?

In humans, MZ B cells are also located in the inner wall of the subcapsular sinus of lymph nodes, the epithelium of tonsillar crypts and the subepithelial area of mucosa-associated lymphoid tissues, including the subepithelial dome of intestinal Peyer’s patches18–21.

What is marginal zone B-cell lymphoma?

Marginal zone lymphoma (MZL) is a group of indolent (slow growing) NHL B-cell lymphomas, which account for approximately eight percent of all NHL cases. The average age at diagnosis is 60 years, and it is slightly more common in women than in men.

What is the treatment for B-cell lymphoma?

Most often, the treatment is chemotherapy (chemo), usually with a regimen of 4 drugs known as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), plus the monoclonal antibody rituximab (Rituxan). This regimen, known as R-CHOP, is most often given in cycles 3 weeks apart.

Is marginal zone lymphoma fatal?

Five-year survival rates are reported as follows: 88.7 percent for MALT, 79.7 percent for splenic MZL, 76.5 percent for nodal MZL. Though the majority of SMZL run an indolent course similar to EMZL, overall, SMZL has poorer outcomes due to a relatively larger proportion of patients who present with aggressive disease.

Is marginal zone B-cell lymphoma curable?

Most patients with nodal marginal zone lymphoma present with advanced stage disease and are not likely to achieve cure, even with aggressive chemotherapy regimens. Moreover, there is little evidence that choice of initial therapy has any impact on survival.

Is marginal zone lymphoma serious?

Can marginal zone lymphoma be cured?

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