How much isosorbide can you take in a day?

Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 160 mg per day. Children—Use and dose must be determined by your doctor.

When should I take isosorbide mononitrate morning or night?

You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a “drug-free” period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time.

How often is isosorbide taken?

Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. The tablet usually is taken two or three times daily. The extended-release tablet usually is taken once daily in the morning. The extended-release capsule usually is taken once daily.

How do you take isosorbide mononitrate ER?

How to use isosorbide mononitrate oral. Take this medication by mouth as directed by your doctor, usually once daily when you wake up. Swallow this medication whole with a half glass of water (4 ounces/120 milliliters) unless your doctor directs you otherwise. Do not crush or chew this medication.

What happens if you take too much isosorbide?

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

Why is the isosorbide mononitrate not taken regularly at 8 am and 8 pm?

To prevent tolerance, it is recommended that the dosage be kept as low as possible and that a sufficiently long nitrate-free interval is ensured to restore sensitivity (first dose in the morning and last dose late in the afternoon, e.g. at 8 am and 15 pm).

How long does isosorbide ER stay in your system?

Isosorbide mononitrate is eliminated from plasma with a half-life of approximately 5.1 hours.

How much does isosorbide mononitrate lower blood pressure?

In 11 patients who received 10 mg of isosorbide dinitrate, blood pressure (BP) dropped from 205 +/- 8/131 +/- 3 to 166 +/- 9/106 +/- 5 mm Hg at 120 minutes. In eight patients who received placebo, BP dropped from 203 +/- 8/130 +/- 3 to 193 +/- 11/122 +/- 5 mm Hg at 120 minutes.

Should I take food with isosorbide mononitrate?

Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your medicine at regular intervals.