What are the doses for temozolomide?

Four weeks after completing the TMZ + RT concomitant phase, TMZ is administered for up to 6 cycles of monotherapy treatment. Dose in Cycle 1 (monotherapy) is 150 mg/m2 once daily for 5 days followed by 23 days without treatment.

How many cycles of temozolomide can you have?

You can have up to 12 cycles of treatment with temozolomide.

How much temozolomide can you take in a day?

Adults—Dose is based on body size and must be determined by your doctor. The starting dose is usually 150 milligrams (mg) per square meter (m[2]) of body size once a day for 5 days, and then you stop taking it for the next 23 days. This dose cycle may be repeated every 28 days, for up to 2 years.

How long can you take temozolomide for?

You might take TEMODAR until your tumor gets worse or for possibly up to 2 years. If your doctor prescribes a treatment regimen that is different from the information in this leaflet, make sure you follow the instructions given to you by your doctor.

What is temozolomide 140 mg used for?

This medication is used to treat certain types of brain cancer. Temozolomide belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

How do you take temozolomide 100mg?

Take your prescribed dose of Temozolomide SUN once a day, preferably at the same time each day. Take the capsules on an empty stomach; for example, at least one hour before you plan to eat breakfast. Swallow the capsule(s) whole with a glass of water.

How long is maintenance Temodar?

Maintenance Phase Treatment Schedule Four weeks after completing the TEMODAR and radiotherapy phase, administer TEMODAR for an additional 6 cycles of maintenance treatment. Dosage in Cycle 1 (maintenance) is 150 mg/m2 once daily for 5 days followed by 23 days without treatment.

What is temozolomide 250 mg used for?

What are the long term side effects of temozolomide?

What are the side-effects of temozolomide?

• Fatigue. People have reported feeling tired during treatment and for up to 12 months afterwards.
• Nausea and vomiting.
• Constipation.
• Loss of appetite.
• Amenorrhoea (an absence of periods)
• Infection.
• Low platelet count.
• Loss of fertility.

Is Temodar cumulative?

The safety of TEMODAR was evaluated in Study MK-7365-006 [see Clinical Studies]. Myelosuppression (thrombocytopenia and neutropenia) was the dose-limiting adverse reaction. It usually occurred within the first few cycles of therapy and was not cumulative.

Does Temodar weaken immune system?

Immune effects of temozolomide as an immunomodulatory agent. Temozolomide is able to affect immune function in brain tumor patients through both effects on tumor cells and direct effects on immune cells.

How toxic is temozolomide?

Management of temozolomide toxicity The most common toxicities with temozolomide were gastrointestinal troubles, such as nausea, vomiting and anorexia. Anti-emetics were administered to 179 patients (73.4%) out of 244 patients who experienced nausea and vomiting.

Can you drink alcohol with temozolomide?

Do not drink alcohol while you are taking temozolomide, even on the off days. Do not take temozolomide if you have an allergy to dacarbazine (DTIC), another chemotherapy medicine. If you have an infection or are prescribed antibiotics by another provider for any reason, call your doctor.

Does temozolomide make you immunocompromised?

Additionally, temozolomide may deplete or expand regulatory T cells (Tregs) which are immunosuppressive depending on the dosing regimen. Immune effects of temozolomide as an immunomodulatory agent.

Is temozolomide well tolerated?

Temozolomide (TMZ) is a well-tolerated, second-generation alkylating agent with excellent penetration into to the CNS and the cerebrospinal fluid (CSF).

What foods should be avoided during chemotherapy?

Avoid citrus, spicy, and strong minty flavors. Avoid dry and sharp foods such as toast, crackers, and chips. Suck on ice chips, popsicles, or frozen fruit. Some chemotherapy medications cause cold intolerance, so avoid this if you have been told to skip very cold foods.

How effective is temozolomide?

Whole brain radiation therapy (WBRT) and temozolomide can be efficacious, with a complete response rate of 85% in one small study.

Can you drink coffee while on chemotherapy?

Avoid caffeine as it acts as a diuretic and draws water out of your cells, causing you to urinate more fluid than you are consuming. Stay away from strong smelling foods to avoid aggravating any disorders of taste. Avoid fatty fried, spicy and overly sweet foods, as they may induce nausea.