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What does cytoplasmic pattern present mean?

What does cytoplasmic pattern present mean?

Cytoplasmic patterns result from antibodies against cytoplasmic components, like Jo-1 or Ribosomal P, and have clinical association with various systemic autoimmune disease, like polymyositis, systemic lupus erythematosus or primary biliary cirrhosis.

What does cytoplasmic positivity mean?

If your results were positive, it may mean you have autoimmune vasculitis. It can also show if cANCAs or pANCAs were found. This can help determine which type of vasculitis you have.

What does a positive ANA with speckled pattern mean?

Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis.

How common is speckled ANA?

The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%).

What does speckled pattern mean?

Speckled pattern correlates with antibody to nuclear antigens extractable by saline; it is found in many disease states, including SLE and scleroderma. When antibodies to DNA and deoxyribonucleoprotein are present (rim and homogenous pattern), there may be interference with the detection of speckled pattern.

Is a speckled ANA pattern normal?

Speckled patterns were the most common patterns. Yilmaz et al.11 reported homogenous pattern in more than half of their patients. In this study, significant associations were found between ANA positivity and RA, SLE and Raynaud phenomenon.

What does speckled pattern ANA mean?

What is the difference between homogeneous and speckled ANA?

Homogenous (diffuse) pattern suggests SLE or other connective tissue diseases. Speckled pattern correlates with antibody to nuclear antigens extractable by saline; it is found in many disease states, including SLE and scleroderma.

Does speckled ANA mean lupus?

Speckled (tiny dots throughout the nucleus)—a common pattern, not specific, but often indicating anti-Sm or anti-RNP antibodies (see below) found in lupus or mixed connective tissue disease.

Can you have a speckled ANA and not have lupus?

A positive ANA does not by itself diagnose lupus since about 10% of normal people and many people with other autoimmune diseases, such as thyroid disease, also have positive tests, but usually less strongly positive. Once positive, an ANA mostly stays positive, so need not be repeated.

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