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What does it mean if macroprolactin is high?

What does it mean if macroprolactin is high?

If prolactin levels are higher than normal, it often means there is a type of tumor of the pituitary gland, known as a prolactinoma. This tumor makes the gland produce too much prolactin. Excess prolactin can cause the production of breast milk in men and in women who are not pregnant or breastfeeding.

What Is percent macroprolactin?

The prevalence of macroprolactin is 1.5%–3.7%. However, in patients who are hyperprolactinemic, the reported prevalence of macroprolactin ranges from 4% to 46% depending on the assay and referral population. Macroprolactin may not have any pathologic significance.

How do you calculate macroprolactin?

The percentage recovery was calculated using initial prolactin (PRL) and post-PEG prolactin concentration (%Recovery = 100 x PRL/post-PEG PRL).

What causes macroprolactin?

It is caused physiologically by pregnancy and pathologically by PRL secreting pituitary adenoma (prolactinoma), hypothalamic and pituitary diseases compressing pituitary stalk, antidopaminergic drugs, hypothyroidism, chest wall diseases, and hepatorenal disorders [3].

What happens if you have macroprolactin?

Patients with macroprolactinemia usually have normal menstrual cycles, minimal galactor-rhea and spontaneous conception. However, some patients may present with clinical symptoms of hyperprolactinemia, if high levels of both macroprolactin and little PRL are present (10).

What does macroprolactin test for?

This test is used to study the causes of high levels of prolactin in the blood. Prolactin is a hormone produced by the pituitary gland (hypophysis), a small gland located at the base of the brain. Its main role is to trigger and maintain the production of breast milk.

What is normal range for macroprolactin?

Reference Interval

Age Male Female
1-9 years 2.1-13.3 ng/mL 2.1-13.3 ng/mL
10 years and older 2.1-13.3 ng/mL 2.8-19.5 ng/mL

What is the difference between prolactin and macroprolactin?

Prolactin is a physiologically active protein that is best known for its role in enabling females to produce milk, while macroprolactin is a physiologically inactive protein isoform of prolactin found in a small proportion in people. Thus, this is the key difference between prolactin and macroprolactin.

What is macroprolactin recovery?

Recovery of less than 40 % after PEG is considered a diagnostic criteria for macroprolactin; recovery values around 40–60 % are considered borderline, and values >60 % rule out macroprolactinemia [22–24]. The unprecipitated percentage of basal prolactin is considered as recovery of monomeric prolactin.

Can macroprolactin cause infertility?

Abstract. Hyperprolactinemia occurs in 15-20 % of women with menstrual disturbances and 30-40 % of infertile women and it can adversely affect the fertility. High molecular weight prolactin (macroprolactin) has long been known in hyperprolactinemic fertile women.

What is macroprolactin screening?

The most common form is macroprolactin, an antibody-antigen complex of prolactin and immunoglobulin G with a molecular mass of 150-170kDa. Macroprolactin can be detected by the prolactin assay but is cleared more slowly than prolactin from the circulation leading to an apparent hyperprolactinaemia.

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