What happens if tamoxifen is given to a patient taking warfarin?

warfarin tamoxifen Combining these medications may significantly increase the effects of warfarin and cause you to bleed more easily. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your INR to safely use both medications.

What is the interaction of PHENobarbital and warfarin?

Interactions between your drugs PHENobarbital can reduce the blood levels of warfarin, which may make the medication less effective in preventing blood clots.

Does capecitabine interact with warfarin?

Discussion: The capecitabine-warfarin interaction is clinically significant, requiring a black box warning in the package insert. The mechanism of action for the interaction is not clear, but may be related to down-regulation of CYP2C9 by capecitabine or its metabolites or a pharmacodynamic interaction with warfarin.

Does hydroxyurea interact with warfarin?

Interactions between your drugs No interactions were found between Coumadin and hydroxyurea. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can you take tamoxifen with blood thinners?

Blood thinners warning If you’re taking a blood thinner medication, tamoxifen can increase the amount of the drug in your body. This may make it easier for you to bleed. If you have ductal carcinoma in situ (DCIS) or a history of blood clots and you must take a blood thinner, you shouldn’t use tamoxifen.

What medications Cannot be taken with warfarin?

Common drugs that can interact with warfarin include:

• Aspirin or aspirin-containing products.
• Acetaminophen (Tylenol, others) or acetaminophen-containing products.
• Antacids or laxatives.
• Many antibiotics.
• Antifungal medications, such as fluconazole (Diflucan)
• Cold or allergy medicines.

Which medication is contraindicated with warfarin?

Common OTC medicines that affect warfarin: Aspirin. Ointments and skin creams with aspirin, such as Aspercreme. Pepto-Bismol® and Alka-Seltzer. Nonsteroidal anti-inflammatory drugs, such as ibuprofen (Motrin® or Advil®) or naproxen (Aleve®)

Can hydroxyurea cause bleeding?

Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow. This may increase the risk that you will develop a serious infection or bleeding.

Does tamoxifen cause blood clots?

Both tamoxifen and raloxifene increase your risk of developing blood clots in a vein in your leg (deep venous thrombosis) or in your lungs (pulmonary embolism). These clots can sometimes cause serious problems, and even death.