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What happens when you inhibit aldosterone?

What happens when you inhibit aldosterone?

By blocking the effects of aldosterone, aldosterone receptor antagonists block the reabsorption of sodium, which encourages water loss. Consequently, this leads to a decrease in blood pressure and a reduction in fluid around the heart.

What are aldosterone side effects?

Abstract. New adverse effects of aldosterone are now apparent: endothelial dysfunction, myocardial fibrosis and LV remodelling. Aldosterone blockade is able to reverse these adverse effects and so reduce mortality in heart failure. Pharmacological differences between spironolactone and eplerenone are discussed.

How do aldosterone inhibitors affect the blood?

Aldosterone receptor antagonists block the effects of aldosterone, preventing the the reabsorption of sodium, which encourages water loss. This leads to a decrease in blood pressure and a reduction in fluid around the heart.

What are side effects of spironolactone?

Spironolactone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • vomiting.
  • diarrhea.
  • stomach pain or cramps.
  • enlarged or painful breasts in men or women.
  • irregular menstrual periods.

Are the side effects of spironolactone reversible?

Spironolactone is taken as daily pills and the effects stop if the medication is discontinued. Prolonged use may have some effects that are permanent and cannot be reversed.

Can too much aldosterone cause weight gain?

The excess aldosterone produced by the adrenal tumor causes salt retention by the kidney, which in turn causes water retention, as the available body water attempts to dilute the salt at a cellular level. The increased salt and water retention causes weight gain and high blood pressure.

What medications block aldosterone?

Aldosterone Antagonists, Selective

  • Aldactone.
  • CaroSpir.
  • eplerenone.
  • finerenone.
  • Inspra.
  • Kerendia.
  • spironolactone.

Is spironolactone an aldosterone blocker?

Spironolactone. Spironolactone is a nonselective aldosterone receptor antagonist that is metabolized extensively in the liver to its active metabolites (the Table). The plasma half-life of the drug is ≈1.4 hours, although in CHF patients with hepatic congestion, this duration may increase 5-fold.

What is the most significant adverse effect of spironolactone?

The most common side effects of spironolactone are: Breast enlargement or swelling (gynecomastia) Elevated potassium levels in the blood (hyperkalemia) Decreased sexual drive.

What are the long term effects of taking spironolactone?

Diuretic effect and menstrual irregularities were the most common adverse effects. Conclusions: After 200 person-years of exposure to spironolactone and 506 person-years of followup over 8 years, no serious illnesses thought to be attributed to spironolactone were reported.

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