What is CD19 Lymphs?

– CD19 is a biomarker for B cell development, lymphoma diagnosis and therapy. Lymphoma is a group of blood cancers that develop from lymphocytes. – CD19 plays a large role in regulating B-cell growth. – CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells.

What is a normal CD19 count?

Reference Range

What does lack of CD19 mean?

Both CD21 and CD19 deficiencies cause hypogammaglobulinemia and reduced memory B cells. CD19 deficiency causes a more severe clinical phenotype. B-cell characteristics reflect this, both after in vitro stimulation as in affinity maturation.

What is the function of CD19 B cells?

Physiological function. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor (BCR)-dependent and independent signaling [16, 17]. It plays roles in the antigen-independent development as well as the immunoglobulin-induced activation of B cells.

Is CD19 a tumor associated antigen?

Unlike cancers such as ALL or CLL in which the tumor cells universally express the B-cell marker CD19, solid tumors rarely express one tumor specific antigen.

What is B cell lymphoma?

B-cell lymphoma is a type of non-Hodgkin lymphoma that originates in the B-cells. It is the most common type of lymphoma and about 85% of all lymphomas in the United States are B-cell.

What does CD stand for in immunology?

cluster of differentiation
CD (cluster of differentiation) Ags are cell surface molecules expressed on leukocytes and other cells relevant for the immune system.