What is FMO3 enzyme?

FMO3 is the primary enzyme in humans which catalyzes the N-oxidation of trimethylamine into trimethylamine N-oxide; FMO1 also does this, but to a much lesser extent than FMO3. Genetic deficiencies of the FMO3 enzyme cause primary trimethylaminuria, also known as “fish odor syndrome”.

Where is the FMO3 gene?

► Gene Function Using quantitative RNase protection assays, Phillips et al. (1995) and Dolphin et al. (1996) determined that FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver.

How do you increase enzyme in FMO3?

Riboflavin, or vitamin B2, may help increase any existing FMO3 enzyme activity in the body. People can take the recommended dosage of 30–40 mg between three and five times a day with meals. People can also avoid using alkaline soaps and body lotions with a high pH level.

How do I get rid of TMAU?

TMAU can’t be cured. But making changes in your diet, using certain soaps and lotions and managing stress can help reduce symptoms….Other ways TMAU may affect people’s wellbeing include:

1. Avoiding people because they’re embarrassed about their condition.
2. Having a hard time developing or maintaining relationships.

How do you get tested for TMAU?

A urine test is used to diagnose trimethylaminuria. The person’s urine is tested to look for higher levels of trimethylamine. Testing can be done by giving choline by mouth followed by urine collection a certain number of times over a 24 hour period.

What foods are good for TMAU?

Treatments for trimethylaminuria

• cows’ milk.
• seafood and shellfish – freshwater fish is fine.
• eggs.
• beans.
• peanuts.
• liver and kidney.
• supplements containing lecithin.

Can TMAU go away?

Treatments for trimethylaminuria There’s currently no cure for trimethylaminuria, but some things might help with the smell.