What is the antidote for myasthenic crisis?

The 2 primary pharmacologic therapies available for myasthenic crisis are intravenous immunoglobulin (IVIg) and plasma exchange (PE) (Table 3). A typical course of IVIg is 400 mg/kg daily for 5 days. Patients should be screened for IgA deficiency to avoid anaphylaxis from IVIg.

What drugs cause myasthenic crisis?

Medications reported to cause exacerbations of myasthenia gravis include the following:

• Antibiotics – Macrolides, fluoroquinolones, aminoglycosides, tetracycline, and chloroquine.
• Antidysrhythmic agents – Beta blockers, calcium channel blockers, quinidine, lidocaine, procainamide, and trimethaphan.

Which drug is contraindicated in myasthenia gravis?

The antibiotics most likely to worsen myasthenia are usually given in hospital, by injection, for very serious infections. The one exceptional drug that must be avoided in myasthenias is the ketolide antibiotic, Telithromycin (Ketek) which has caused deaths.

Can neostigmine cause cholinergic crisis?

Neostigmine, like other AChE inhibitors, can stimulate the muscarinic receptors and cause the cholinergic crisis. Bronchospasm, miosis, increased peristalsis, and secretions are usually seen after administration of neostigmine.

Why is Cipro contraindicated in myasthenia gravis?

Worsening of myasthenia gravis (a disease which causes muscle weakness). Fluoroquinolones like CIPRO may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems.

Why atropine is given before neostigmine in myasthenia gravis?

At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects such as bradycardia and profuse secretion. Atropine has been used to prevent those side effects of neostigmine.

What is the drug atropine used for?

Ophthalmic atropine is used before eye examinations to dilate (open) the pupil, the black part of the eye through which you see. It is also used to relieve pain caused by swelling and inflammation of the eye.

Why Physostigmine is not used in myasthenia gravis?

Myasthenia gravis is an autoimmune disorder that leads to muscle weakness by reducing the density of neuromuscular nicotinic receptors. Thus, pyridostigmine increases acetylcholine levels in the neuromuscular junctions, with a consequent increase in motor tone.