What is the prognosis of platinum resistant ovarian cancer?
What is the prognosis of platinum resistant ovarian cancer?
Platinum-resistant ovarian cancer has a median survival of 9–12 months and less than 15% respond to subsequent chemotherapy (Davis et al. 2014). Ultimately, almost all HGSOC patients become platinum resistant and succumb to the disease (Davis et al.
How many ovarian cancer patients are platinum resistant?
Although up to 25% of women with ovarian cancer have innately (or primary) platinum-refractory disease, most patients are sensitive to front-line platinum therapy but will unfortunately develop recurrence and acquire progressive resistance over time.
What is primary platinum refractory ovarian cancer?
Primary platinum-refractory/-resistant ovarian cancers are quite uncommon and are usually seen with nonserous ovarian cancers, such as clear cell carcinoma, mucinous carcinoma, or low-grade serous carcinoma, rather than the more common high-grade serous carcinoma.
What is the difference between platinum sensitive and platinum resistant?
Patients with a PFI of six months or longer are considered to have chemotherapy-sensitive disease (often also termed “platinum-sensitive”). Patients with a PFI of less than six months are considered to have chemotherapy-resistant disease (often also termed “platinum-resistant”).
What does it mean to be platinum resistant?
(PLA-tih-num reh-ZIH-stunt KAN-ser) Cancer that responds at first to treatment with drugs that contain the metal platinum, such as cisplatin and carboplatin, but then comes back within a certain period. For example, ovarian cancer that comes back within 6 months after treatment is considered platinum resistant.
What is the survival rate of recurrent ovarian cancer?
Ovarian cancer recurs in most patients, with a 5-year survival rate less than 30%.
What is the treatment for platinum resistant ovarian cancer?
Platinum-resistant These include paclitaxel (Taxol®) – often given once per week rather than every three weeks – or pegylated liposomal doxorubicin hydrochloride (PLDH or Caelyx®). In platinum-resistant ovarian cancer, these drugs are usually given on their own.
What does platinum refractory mean?
For example, “platinum-refractory” is defined as cases in which the disease progresses during platinum-based therapy; “platinum-resistant” is defined as cases in which the disease relapses within 6 months after the end of platinum treatment; and “platinum-sensitive” is defined as cases in which the disease relapses at …
What causes platinum resistance?
Several mechanisms contribute to the development of drug resistance, including tumor heterogeneity, reduced drug concentration to the target, alteration in drug target structure, increased repair of the lesions induced. Depending on the drug and tumor under investigation, one or more mechanisms can take place.
What is platinum resistant chemo?
Cancer that responds at first to treatment with drugs that contain the metal platinum, such as cisplatin and carboplatin, but then comes back within a certain period. For example, ovarian cancer that comes back within 6 months after treatment is considered platinum resistant.
Is recurrent ovarian cancer always fatal?
Recurrent ovarian cancer is a lethal disease, and few patients can be cured. Although most patients receive standardized surgery and chemotherapy, the status of recurrent disease is heterogeneous. The site of recurrence and the survival intervals after recurrence are also widely distributed.
Can recurrent ovarian cancer go into remission?
About 80% of women who are diagnosed with ovarian cancer will go into remission after their initial treatment, but around 60% will then have a recurrence. The goal of maintenance therapy is to delay a cancer recurrence or to reduce the risk of it recurring at all.
What does platinum resistant cancer mean?
Can you beat recurrent ovarian cancer?
Ovarian cancer often comes back (relapses) after treatment. This is also called recurrent cancer. The main treatment for recurrent ovarian cancer is anti cancer drug treatment (chemotherapy). You also might have surgery or targeted cancer drugs.
Why use platinum-based chemotherapy?
Platinum-based drugs are effective against cancer because at their centre is a platinum atom joined to two ammonion molecules and two chloride ions. The compound is negatively charged, but when it enters the cancer cell it becomes positively charged because the chloride ions are replaced by water molecules.
What happens when Avastin stops working?
If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant. Planning to become pregnant. Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children.
How long do people with recurrent ovarian cancer live?
Due to the poor prognostic outlook of women with recurrent disease and median survival times between 5 and 17 months (2), women with recurrent ovarian cancer rarely survive for a long time.
How many times can you have chemotherapy for recurrent ovarian cancer?
Continued Standard Chemotherapy: The standard course of initial chemotherapy is approximately 6 cycles, or about 4 months of treatment. If, after 6 cycles, there is a small amount of persistent cancer, some doctors feel further chemotherapy treatment for 10 or 12 cycles may continue to cause shrinkage of the cancer.
What is the life expectancy after ovarian cancer?
Recurrence rates. Multiple factors affect the risk of ovarian cancer recurrence,including the stage at which the cancer was originally diagnosed and treated.
What is platinum resistance?
… In recurrent epithelial ovarian cancer (EOC) most patients develop platinum-resistance. On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced.
What is the cure for ovarian cancer?
– Cancer Research UK: chemotherapy for ovarian cancer – Macmillan: chemotherapy treatment – Ovacome: ovarian cancer treatments
What is platinum sensitive ovarian cancer?
Platinum-sensitive ovarian cancer — If the initial treatment with chemotherapy worked, and the response lasted for at least six months, a woman is considered to have “platinum-sensitive” cancer. For these women, at the time of relapse, retreatment with another cycle of platinum-based chemotherapy is usually recommended.