Which layer of epidermis has intercellular bridges?
Which layer of epidermis has intercellular bridges?
Keratinocytes
| Layer | Cell type |
|---|---|
| Stratum spinulosum (spinous, spiny or prickle cell layer) | Intercellular bridges called desmosomes link the cells together. The cells become increasingly flattened as they move upward. |
What epidermal layers has intercellular connections?
The epidermis has 2 major barrier structures: stratum corneum, the outmost layer and tight junctions, intercellular junctions that seal adjacent keratinocytes in the stratum granulosum, found below the stratum corneum.
What are the 5 zones of the epidermis?
The epidermis is subdivided into five layers or strata:
- stratum basale.
- stratum spinosum.
- stratum granulosum.
- stratum lucidum.
- stratum corneum.
What is the stratum granulosum?
The stratum granulosum comprises keratinocytes that have matured to the point where they are beginning to produce the large amounts of keratin that will eventually fill the cells. From: Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research, 2019.
What are intercellular connections made of proteins called?
Adherens junctions: Transmembrane proteins called cadherins (see Fig. 30.5) link neighboring cells and connect to actin filaments in the cytoplasm. Desmosomes: Another type of cadherin links cells together and connects to cytoplasmic intermediate filaments.
How is the epidermis and dermis connected?
The dermis is connected to the epidermis at the level of the basement membrane and consists of two layers, of connective tissue, the papillary and reticular layers which merge together without clear demarcation. The papillary layer is the upper layer, thinner, composed of loose connective tissue and contacts epidermis.
What makes up the epidermis?
The epidermis of the skin is a constantly renewing stratified squamous epithelium. It consists mostly of keratinocytes, but also of Langerhans cells, melanocytes, and Merkel cells resting on a supporting dermis that contains the nerve and vascular networks, which nourish the epidermis.
What are the 5 layers of the epidermis from innermost to outermost?
From innermost to outermost the layers are: stratum basale, stratum spinosum, stratum granulosum, and stratum corneum.
- Stratum basale. The deepest/innermost layer of the epidermis is the stratum basale.
- Stratum spinosum.
- Stratum granulosum.
- Stratum corneum.
