How do you manage reperfusion syndrome?

Treatment is generally supportive. Pain is usually managed using non-steroidal anti-inflammatories and edema can be controlled with compression stockings (if there is adequate skln perfusion). Medical management of reperfusion injury in the setting of critical limb ischemia has not been investigated.

What is the main clinical problem arising from reperfusion syndrome?

Reperfusion leads to biochemical imbalances within the cell that lead to cell death and increased infarct size.

How can reperfusion syndrome be prevented?

First, optimizing CPR quality is a key component in order to limit reperfusion injury. Second, post-resuscitation care that targets normal oxygenation (avoiding hyper or hyopoxia), normocapnia, and normal blood pressure post ROSC seem to be of major importance.

What should be included in reperfusion therapy?

Reperfusion therapy includes drugs and surgery. The drugs are thrombolytics and fibrinolytics used in a process called thrombolysis. Surgeries performed may be minimally-invasive endovascular procedures such as a percutaneous coronary intervention (PCI), which involves coronary angioplasty.

Who is eligible for reperfusion therapy?

Currently, the primary criterion for candidate selection in reperfusion is the time from stroke symptom onset. Reperfusion therapy must be administered within a narrow window time of up to 4.5 h after symptom onset for IV-tPA, and up to 6–8 h for endovascular MT.

What priority nursing interventions should be implemented for the patient with ACS?

General priorities for patients with ACS are haemodynamic monitoring and close observation of vital signs. A review of fluid status can provide information about renal perfusion, as some patients may present with, or develop, heart failure.

What factors influence reperfusion injury?

Reperfusion injury results from several complex and interdependent mechanisms that involve the production of reactive oxygen species, alterations in intracellular calcium handling, microvascular and endothelial cell dysfunction, altered myocardial metabolism, and activation of neutrophils, platelets and complement.