What is bovine fetuin?

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa.

What is the role of fetuin?

Fetuin-A mediates the formation of stable colloidal mineral-protein complexes called calciprotein particles (CPPs). Thus, fetuin-A is important in the stabilization and clearance of amorphous mineral precursor phases.

How do I increase my fetuin?

It is put forward that some nutrients such as dairy products, curcumin, niacin, palmitate, coffee and alcohol consumption decrease fetuin-A level, and dietary omega-3 fatty acids intake may increase fetuin-A concentration.

How many O-glycosylation sites are there in bovine fetuin?

Bovine fetuin often finds use as a test model for analytical methods, but the exact occupancy of its O-glycosylation sites has not yet been determined. An obstacle for a closer inspection of the five or six O-glycosylation sites is the close spacing of several sites on the same tryptic peptide.

What is the source of fetal bovine fetuin?

Bovine fetuin (fetuin-A) was obtained from Sigma Aldrich (Vienna, Austria; # 3004, lot 109K7425V). An alternative source was heat inactivated fetal bovine serum (HI FBS, 10082-147, lot 826065). An alternative source was heat inactivated fetal bovine serum (Gibco, Invitrogen, Carlsbad, CA, USA).

Can serum fetuin-A Levels serve as a biomarker for ectopic calcification?

Fetuin-a is a multifunctional protein that acts as a strong local and systemic inhibitor of VC. Along with serum and liver levels of fetuin-a, it is interesting to hypothesize that quantification of the serum fetuin-mineral complexes might as well serve as a novel biomarker for ectopic calcification.

Are there asparagine-linked oligosaccharides on bovine fetuin?

The asparagine-linked oligosaccharides on bovine fetuin. Structural analysis of N-glycanase-released oligosaccharides by 500-megahertz 1H NMR spectroscopy