What is meant by retro synthesis?

Retrosynthesis is a method of chemical synthesis which involves “deconstructing” a target molecule into its readily available, simple starting materials in order to assess the best synthetic route.

What is retro in chemistry?

Retro = Backwards. Synthesis = The process of combining simpler reactions to form a chemical compound/molecule. In your Organic Chemistry course, this is presented in the form of a complex molecule that you are then asked to synthesize from a given starting molecule, or a set of reaction conditions.

What is synthetic planning?

Definition. 4. Synthesis is a construction process that involves converting simple or commercially available molecules into complex molecules using specific reagents associated with known reactions in the retrosynthetic scheme.

What is synthetic equivalent in retrosynthesis?

Retrosynthetic analysis The formation of any C-C bond involves the union of an electrophilic acceptor synthon and a nucleophilic donor synthon. Synthetic equivalents are the chemical species which is used to generate synthons. They are the actual substrates used for the forward reaction and hence forward synthesis.

Is retrosynthesis working backwards?

The same thing applies to multistep synthesis (working backwards like this is a technique termed retrosynthesis). Look at your product, and think of all the reactions that you know of that could form it, ignoring your starting material.

What is synthon and synthetic equivalent give examples?

Synthetic equivalent is a reagent that carries out the function of a synthon. Synthons are reacted with the corresponding synthetic equivalent to obtain the desired target molecule. For example, the synthetic equivalent for carboxylic acid group in the synthesis of phenylacetic acid is cyanide anion.

What is synthon give an example?

An example of a carbanionic synthon for an ester enolate is shown in fig. 1. A carbon-carbon bond alpha to a carbonyl can usually be disconnected to an enolate equivalent and a carbon electrophile. In this case, the enolate is generated by direct deprotonation of the substrate with lithium diisopropyl amide (LDA) base.

What is retrosynthesis used for?

Retrosynthesis is well suited for discovering different synthetic routes and comparing them in a logical and straightforward fashion. A database may be consulted at each stage of the analysis, to determine whether a component already exists in the literature.