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What is Xanthinuria?

What is Xanthinuria?

Description. Collapse Section. Hereditary xanthinuria is a condition that most often affects the kidneys. It is characterized by high levels of a compound called xanthine and very low levels of another compound called uric acid in the blood and urine. The excess xanthine can accumulate in the kidneys and other tissues.

What enzyme breaks down purine?

The enzyme responsible for purine metabolism is uricase (urate oxidase, oxidoreductase, EC 1.7. 3.3).

What causes hyperuricemia?

Hyperuricemia can occur as a result of your body producing too much uric acid or getting rid of too little. You have a purine-rich diet. Foods high in purine include some organ meats, game, herrings and a few other types of seafood, and beer. Your body’s cells break down due to exercise and certain other conditions.

Where is xanthine oxidase found?

Xanthine oxidase is a superoxide-producing enzyme found normally in serum and the lungs, and its activity is increased during influenza A infection. During severe liver damage, xanthine oxidase is released into the blood, so a blood assay for XO is a way to determine if liver damage has happened.

What are high-purine foods?

High-Purine Foods Include:

  • Alcoholic beverages (all types)
  • Some fish, seafood and shellfish, including anchovies, sardines, herring, mussels, codfish, scallops, trout and haddock.
  • Some meats, such as bacon, turkey, veal, venison and organ meats like liver.

How is hyperuricemia diagnosed?

How hyperuricemia is diagnosed. Your doctor may order blood and urine tests to measure creatinine levels, which determines kidney function, as well as uric acid levels. Blood is usually taken from a vein in your arm, typically on the inside of your elbow or on the back of your hand.

Is hyperuricemia a disease?

Symptoms of Hyperuricemia This is a disorder where uric acid builds up in the tissues and blood and leads to painful joints, particularly in your big toe. ‚ÄĆAnother common symptom of hyperuricemia is the formation of kidney stones, which can lead to sharp pain in the abdomen or side, nausea, and vomiting.

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