Why is fondaparinux given in ACS?
Why is fondaparinux given in ACS?
Fondaparinux provides a prophylactic level of anticoagulation and thus this will also act as a thromboprophylactic agent in these patients. As Fondaparinux at this dose provides a prophylactic level of anticoagulation it is not suitable for indications where a therapeutic level of anticoagulation is required eg.
Why do we give fondaparinux in Nstemi?
Importance Fondaparinux was associated with reduced major bleeding events and improved survival compared with low-molecular-weight heparin (LMWH) in a large randomized clinical trial involving patients with non–ST-segment elevation myocardial infarction (NSTEMI).
Do you give fondaparinux in STEMI?
In conclusion, fondaparinux significantly reduced mortality without increasing severe bleeding in patients with STEMI. Overall, the data from the OASIS studies showed that fondaparinux 2.5 mg may represent a new anticoagulant standard in patients with acute coronary syndromes.
Why is fondaparinux not used?
Because of its renal clearance, fondaparinux is contraindicated in patients with creatinine clearance lower than 30 mL/min, and it should be used with caution in those with a creatinine clearance lower than 50 mL/min.
Why is fondaparinux used instead of enoxaparin?
Fondaparinux is an alternative to enoxaparin because it preserves short-term efficacy but substantially reduces bleeding. This effect translates into lower long-term rates of death, myocardial infarction, and stroke.
Which is better enoxaparin or fondaparinux?
First, in the short term, fondaparinux and enoxaparin have similar efficacy. Second, as compared with enoxaparin, fondaparinux substantially reduces bleeding. Third, the reduced bleeding that accompanies the use of fondaparinux is associated with lower long-term mortality and morbidity.
What is the difference between LMWH and fondaparinux?
Fondaparinux is essentially a synthetic derivative of LMWH. It is provided in relatively fixed doses, usually q24hrs. Fondaparinux in contraindicated in patients with renal dysfunction (GFR < 30 ml/min).
