What is reperfusion arrhythmia?

Reperfusion arrhythmias originate as a consequence of the complex of cellular and humoral reactions accompanying the opening of coronary artery. As the primary cause of their generation are considered the chemically defined substances that are produced and accumulated in myocardium during reperfusion.

What is the most common reperfusion arrhythmia?

In humans, the most common reperfusion arrhythmia is an accelerated idioventricular rhythm. However, ventricular tachycardia and ventricular fibrillation remain the most important causes of sudden death following spontaneous restoration of antegrade flow.

How is reperfusion therapy done?

Reperfusion therapy includes drugs and surgery. The drugs are thrombolytics and fibrinolytics used in a process called thrombolysis. Surgeries performed may be minimally-invasive endovascular procedures such as a percutaneous coronary intervention (PCI), which involves coronary angioplasty.

What medicine helps arrhythmia?

Antiarrhythmic drugs

• amiodarone (Cordarone, Pacerone)
• flecainide (Tambocor)
• ibutilide (Corvert), which can only be given through IV.
• lidocaine (Xylocaine), which can only be given through IV.
• procainamide (Procan, Procanbid)
• propafenone (Rythmol)
• quinidine (many brand names)
• tocainide (Tonocarid)

What is reperfusion of the heart?

INTRODUCTION. Myocardial injury in the setting of an acute myocardial infarction (MI) is the result of ischemic and reperfusion injury. Reperfusion therapies, including primary percutaneous coronary intervention and fibrinolytic therapy, promptly restore blood flow to ischemic myocardium and limit infarct size.

Why does thrombolysis treatment cause arrhythmias?

When high-grade ventricular arrhythmias occur after thrombolytic therapy for acute myocardial infarction, they are often attributed to successful reperfusion of the infarcted myocardium. This analysis of data from 2546 patients in the Thrombolysis in Myocardial Infarction (TIMI) Phase II study suggests the opposite.

Is CABG a reperfusion therapy?

Reperfusion of an ischemic area may result, however, in paradoxical cardiomyocyte dysfunction, a phenomenon termed “reperfusion injury.” Modalities for reperfusion include not only thrombolysis, but also percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and cardiac transplantation.

What is the most effective antiarrhythmic drug?

Amiodarone is considered the most potent antiarrhythmic agent. The adverse event profile with amiodarone can be intolerable, with gastrointestinal effects the most common side effect.